Evaluation of Systemic Immune Inflammation (SII) Index in Oral Squamous Cell Carcinoma - Exploring its Role as a Predictor Marker for Recurrence

Kalyani N and Chandra J

Department of Oral and Maxillofacial Surgery, Yenepoya Dental College, India

^*Correspondance to: Nupur Kalyani 

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Abstract:

Purpose: Oral Squamous Cell Carcinoma (OSCC) is a major cause of morbidity and mortality each year. Various biomarkers like Neutrophil-Lymphocyte Ratio (NLR), Platelet Lymphocyte Ratio (PLR), have been validated as prognostic indicators. The Systemic Immune Inflammation (SII) index which combines neutrophils, lymphocytes, and platelets, was recently developed as a collaborative tool to provide prognostic information for patients with hepatocellular carcinoma, and pancreatic cancer, and germ cell tumors. This study aims to evaluate the relevance of the SII index in OSCC, to explore its role as a predictor marker for predicting recurrences, node involvement. Methods: 34 patients with biopsy-proven OSCC fulfilling the inclusion and exclusion criteria were enrolled in this longitudinal study. SII index were calculated at three-time intervals – preoperatively, at 6- and 12-months postoperatively. Results: On comparing the values of the SII index over 1 year with the treatment modality chosen (with RT and without RT), higher values were noted in the patients who underwent surgery with RT. SII values in relation to different TNM stages were seen as statistically significant at 1 year with a steady increase in values in T2 and T3 groups. Recurrence was seen only in one patient who had also shown a significant rise in SII values post-surgery. Conclusion: According to our study, we can conclude that the SII index at regular intervals could be used to identify patients with an increased chance of recurrence.

Keywords:

Platelets; Neutrophils; Lymphocyte; SII; OSCC; Recurrence; Predictor; TNM; Radiotherapy; Prognosis

Cite the Article:

Kalyani N, Chandra J. Evaluation of Systemic Immune Inflammation (SII) Index in Oral Squamous Cell Carcinoma - Exploring its Role as a Predictor Marker for Recurrence. Clin Oncol. 2024;9:2074..