Two Cases of Thoracic SMARCA4-Deficient Undifferentiated Tumor: A Case Report

Zhang S, Xu W, Wu S, Chen M, Huang J, Sun Q and Zhou Y

Department of Radiation Oncology, First Affiliated Hospital, Bengbu Medical College, China
Department of Pathology, First Affiliated Hospital, Bengbu Medical College, China

^*Correspondance to: Yufu Zhou 

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Abstract:

Objective: To investigate the clinical and pathological features of thoracic SMARCA4-deficient undifferentiated tumor.
Methods: The clinical data, images, histopathological features, treatment regimens, and follow-up results of two cases of SMARCA4-deficient undifferentiated tumor diagnosed by clinicians at the First Affiliated Hospital of Bengbu Medical College were retrospectively analyzed.
Results: Both patients were male, aged 65 and 81 years, respectively, and both had a history of smoking. The images showed that both patients had lung masses and mediastinal enlarged lymph nodes. Histopathological analysis revealed that the tumor cells had a solid structure formed by epithelioid/rhabdoid cells, and the tumor cells were distributed in islands or scattered
with extensively necrotic regions, and no evidence of epithelioid differentiation was observed. Immunohistochemical staining demonstrated that the cells were negative for SMARCA4 expression and positive for SOX2 and SMARCB1 expression. The overall survival rates of patients 1 and 2 were 12.0 and 3.2 months, respectively.
Conclusion: Thoracic SMARCA4-deficient undifferentiated tumor is a rare thoracic malignancy, and its diagnosis depends on histopathological and immunohistochemical analyses by experienced pathologists.

Keywords:

Thoracic tumor; SMARCA4; Thoracic SMARCA4-deficient undifferentiated tumor; Immunohistochemistry

Cite the Article:

Zhang S, Xu W, Wu S, Chen M, Huang J, Sun Q, et al. Two Cases of Thoracic SMARCA4-Deficient Undifferentiated Tumor: A Case Report. Clin Oncol. 2022;7:1964..