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Abstract
Citation: Clin Oncol. 2022;7(1):1962.DOI: 10.25107/2474-1663.1962
Assessment of Carcinogenicity in Rodents Through Inhalation Exposure to Cyclohexanone
Seo DS, Lim CH, Jo JM, Kim TH and Lee YH
Inhalation Toxicity Research Center, Occupational Safety and Health Research Institute, Republic of Korea
*Correspondance to: Dong Seok Seo
PDF Full Text Research Article | Open Access
Abstract:
Purpose: Cyclohexanone is a widely used chemical in various industries, and there are concerns about its carcinogenicity to workers in the workplace. Therefore, the purpose of this study is to evaluate the carcinogenicity of cyclohexanone through inhalation exposure.
Methods: In order to evaluate carcinogenicity of cyclohexanone, two species of F344 rat and B6C3F1 mouse were used as experimental animals. For the carcinogenicity test, three exposure groups and a control group were set for each two species. Fifty animals were assigned to each test group, exposure concentrations of 20, 60, and 200 ppm for rats and 50, 150, and 450 ppm for mice were set, 6 h a day, 5 days a week, and the rats were exposed 24 months, mice were exposed for 18 months. Then, the
occurrence of exposure-related tumors was analyzed.
Results: In the experimental results, no increase in the incidence of neoplasms or tumors related to exposure to cyclohexanone was observed in either species. From these results, the carcinogenicity of cyclohexanone was not recognized.
Conclusion: We believe that these results could be presented as additional evidence that cyclohexanone does not cause cancer in animals, and that it is not carcinogenic in the respiratory system. Furthermore, we think that it could be presented as additional evidence for the re-evaluation of carcinogenicity classification for cyclohexanone in institutions related to carcinogenicity
classification and evaluation.
Keywords:
Cyclohexanone; Carcinogenicity; Inhalation; F344 rats; B6C3F1 mice
Cite the Article:
Seo DS, Lim CH, Jo JM, Kim TH, Lee YH. Assessment of Carcinogenicity in Rodents Through Inhalation Exposure to Cyclohexanone. Clin Oncol. 2022;7:1962..