Journal Basic Info

  • Impact Factor: 2.709**
  • H-Index: 11 
  • ISSN: 2474-1663
  • DOI: 10.25107/2474-1663
**Impact Factor calculated based on Google Scholar Citations. Please contact us for any more details.

Major Scope

  •  Kidney Cancer
  •  Neoadjuvant Therapy
  •  Colon Cancer
  •  Stomach Cancer
  •  Paediatric Cancers
  •  Immunology
  •  Head and Neck Oncology
  •  Melanoma/Skin Cancer

Abstract

Citation: Clin Oncol. 2021;6(1):1873.DOI: 10.25107/2474-1663.1873

Quantitative Evaluation of the Relationship between Magnetic Resonance Elastic Value and Pathological Grade of Hepatocellular Carcinoma by Magnetic Resonance Elastography

Zong-Tai Li, Chun-Yan Chen M, Dong-Sheng Zhang, Shui-Qing Zhuo, Gui-Xiao Xu, De-Le Deng, Hai-Bin Liu, Bao-Dan Liang, Zhi-Yue Lin, Xiao-Ting Zhang, Wen-XingZhong, Jun-Wei Huang, Chuan-Miao Xie, Yi-Zhuo Li and Hao-Qiang He

State Key Laboratory of Oncology in Southern China, Cancer Center, Sun Yat-sen University, Collaborative Innovation Center for Cancer Medicine, Guangzhou, China
Medical Imaging Technology Major, Guangzhou Xinhua College, China
Grade 2018, Intern in Cancer Center, Sun Yat-sen University, China
Department of Radiation Oncology, Sun Yat-sen University, China
Department of Medical Oncology, Sun Yat-sen University, China
Imaging Diagnosis Center, Sun Yat-sen University, China
Grade 2017, Intern in Cancer Center, Sun Yat-sen University, China
These authors contributed equally to this study

*Correspondance to: Yi-Zhuo Li 

 PDF  Full Text Research Article | Open Access

Abstract:

Objectives: To try another non-invasive method to evaluate the relationship between Magnetic Resonance (MR) elastic value and pathological grade of Hepatocellular Carcinoma (HCC) using Magnetic Resonance Elastography (MRE).
Methods: Forty-seven HCC patients underwent MR Imaging (MRI), elastography in the upper abdomen. The elastic value of the lesion area was measured, and that of the normal liver tissue was measured adjacent to the lesion area at the same level. The Mann-Whitney U test was used to compare the difference in elasticity between the lesion area and normal area, and the difference between the low and middle-high differentiation groups. The Receiver Operating Characteristic Curve (ROC) of the lesion area and normal area in the complete case group and different differentiation groups were used to determine the diagnostic cut-off value to distinguish the lesion area from the normal area in each group.
Results: (1) There was a significant difference in elasticity between the normal area and HCC area (p<0.001). The diagnostic cut-off value was 4842 Pa. (2) There was a significant difference in elasticity between the low-and middle-high differentiation groups (p<0.001). The diagnostic cut-off value was 10456 Pa. (3) There was a statistically significant correlation between the elastic value on MRE and degree of pathological differentiation of HCC in the two groups (p<0.001).
Conclusion: The elastic value of HCC measured using MRE can be used to evaluate the degree of pathological differentiation of HCC. MRE may be a non-invasive and reliable method for evaluating the pathological grade of HCC.

Keywords:

Magnetic resonance elastography; Liver fibrosis; Hepatocellular carcinoma; Pathological grading

Cite the Article:

Li Z-T, Chun-Yan Chen M, Zhang D-S, Zhuo S-Q, Xu G-X, Deng D-L, et al. Quantitative Evaluation of the Relationship between Magnetic Resonance Elastic Value and Pathological Grade of Hepatocellular Carcinoma by Magnetic Resonance Elastography. Clin Oncol. 2021;6:1873..

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