Inflammation, Oxidative Stress and Cobalt Deficiency in Acute Childhood Leukemia

Moses O Akiibinu, Bashiru S Oseni , Adekunle A Adesiyan, Susanah O. Akiibinu and John I Anetor

Department of Chemistry and Biochemistry, Caleb University Lagos, Nigeria Department of Medical Laboratory Sciences, Ladoke Akintola University, Nigeria Department of Chemical Pathology, University of Ibadan, Nigeria Department of Clinical Nursing, University College Hospital, Nigeria

^*Correspondance to: Moses O Akiibinu 

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Abstract:

Background: Despite increasing incidence of childhood leukemia in Nigeria, the pathophysiology remains poorly researched. The present study determined the levels of cobalt, C-reactive protein and markers of oxidative stress in children with acute leukemia. Methods: Twenty-five (15 males, 10 females; age range: 3 to 14 years) newly diagnosed children with acute lymphoblastic leukemia were recruited for this study. Another twenty five (14 males, 11 females; age: 4-14 years) apparently healthy children without acute leukemia, septicemia or metabolic disorders at the time of the study served as controls. Plasma levels of cobalt, C-Reactive Protein (CRP), Total Plasma Peroxides (TPP), Malondialdehyde (MDA) and Total Antioxidant Potential (TAP) were determined in them using atomic absorption spectrophotometry, single radial immunodiffusion and spectrophotometry methods respectively. Level of Oxidative Stress Index (OSI) was calculated as percent ratio of TPP and TAP. Results: The results showed significantly (p<0.05) higher plasma levels of TPP, OSI and MDA in acute leukemia children compared with controls. Plasma levels of TAP and cobalt reduced significantly (p<0.05) in children with acute leukemia compared with controls. The plasma level of OSI correlated significantly with TPP (r=0.78; p<0.001), TAP (r= -0.73; p<0.001), CRP (r=0.64; p<0.001) and cobalt (r= -0.33; p=0.018) in acute leukemia. Conclusion: This study confirmed oxidative stress and inflammatory responses as features of childhood acute leukemia. The oxidative stress and cobalt deficiency could call for micronutrients supplementation as adjuvant therapy in the treatment of acute lymphoblastic leukemia.

Keywords:

Acute leukemia; C-reactive protein; Oxidative stress; MicronutrientAkiibinu MO, Oseni BS, Adesiyan AA, Anetor JI. Inflammation, Oxidative Stress and Cobalt Deficiency in Acute Childhood Leukemia. Clin Oncol. 2019; 4: 1663

Cite the Article:

Akiibinu MO, Oseni BS, Adesiyan AA, Anetor JI. Inflammation, Oxidative Stress and Cobalt Deficiency in Acute Childhood Leukemia. Clin Oncol. 2019;4:1663.