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**Impact Factor calculated based on Google Scholar Citations. Please contact us for any more details.Major Scope
- Urological Cancers
- Targeted Therapy
- Stomach Cancer
- Kidney Cancer
- Head and Neck Oncology
- Adjuvant Therapy
- Central Nervous System Tumors
- Colorectal Cancer
Abstract
Citation: Clin Oncol. 2019;4(1):1605.DOI: 10.25107/2474-1663.1605
Efficacy and Safety of First-Line Pazopanib in Patients with Metastatic Renal Cell Carcinoma: Real-Life Multi Institutional Experience
Abeer Hussien Anter, Rasha Hamdy Hamed and Amrallah A Mohammed
Department of Clinical Oncology and Nuclear Medicine, Mansoura University, Egypt
Department of Medical Oncology, Zagazig University, Egypt
*Correspondance to: Abeer Hussien Anter
PDF Full Text Research Article | Open Access
Abstract:
Background: Pazopanib is an oral multi targeted tyrosine kinase inhibitor that has been approved for first-line treatment of metastatic Renal Cell Carcinoma (mRCC). This trial aimed to investigate the real-life clinical outcomes of the first-line pazopanib in Egyptian patients with mRCC.Patients and
Methods: Data from 30 patients with mRCC, treated with pazopanib at our institutions during the period from January 2016 to December 2018, were analyzed retrospectively. All patients received 800 mg/day pazopanib. The primary end point was Progression-Free Survival (PFS). Secondary end points included overall survival, tumor response rate, and safety.Results: Thirty patients were included 23 (76.7%) male and 7 (23.3%) female, of median age 53 years (range, 20-76 years). Clear cell pathology was reported in 80%. Lung and Lymph nodes were the most common sites of metastasis 53.3%, 46.7 respectively. Most AEs were grade 1/2, Diarrhea (33.3%), hypertension (26.7%), and stomatitis (23.3%) were the most common AEs reported while thrombocytopenia was the most common hematological toxicities. The median PFS was 9 months (95% CI 7.12-10.87) and the median OS was 28 months. The estimated 2-year survival rate was 57%. The objective response rate was 30%.Conclusion: This study proved that pazopanib treatment has clinically acceptable efficacy and safety profile in unselected real-world Egyptian patients with mRCC.
Keywords:
Metastatic renal cell carcinoma; Pazopanib; First-line; Efficacy
Cite the Article:
A. Efficacy and Safety of First-Line Pazopanib in Patients with Metastatic Renal Cell Carcinoma: Real-Life Multi Institutional Experience. Clin Oncol. 2019; 4: 1605.