Clin Oncol | Volume 3, Issue 1 | Review Article | Open Access

Impact of Dietary Intervention in Patients with Cardiac Arrhythmias on HOMA-IR and Echocardiographic Parameters. A Randomized Double Blind, Placebo- Controlled Pilot Study

Parsi E^1*, Bitterlich N², Winkelmann A¹, Rösler D⁴ and Metzner C⁴

¹Department of Cardiology, Bonn Education Association for Dietetics, Germany
²Department of Biostatistics, Medicine and Service Ltd, Germany
³Depaertment of dietetics, Bonn Education Association for Dietetics, Germany
⁴Department of Internal Medicine, Uniklinik RWTH Aachen, Germany

^*Correspondance to: Parsi E 

Abstract

Causes of cardiac arrhythmias are often components of metabolic syndrome and/or electrolyte disturbances. In the latter case, magnesium and potassium are of high importance. In our pilot study we randomized 60 patients with cardiac arrhythmias and cardiovascular comorbidities. The patients of the verum group were a dietary intervention with specific micronutrients over a treatment period of six weeks. We found in the verum group a significant reduction in elevated fasting insulin (p=0.053) as well as in HOMA-IR (p=0.053). In this group also significant improved the echo parameters, like EF in range 54 – 65% (p=0.020), and LVMI (p<0.003) as well as the tendency LVEDD (p=0.050), IVS (p=0.053) and E/A ratio (p=0.051). However, there is no significant group difference in these parameters. These results seem to indicate that the specific micronutrient combination in patients with cardiac arrhythmias reduces insulin resistance and improves left ventricular cardiac function.

Citation:

Parsi E, Bitterlich N, Winkelmann A, Rösler D, Metzner C. Impact of Dietary Intervention in Patients with Cardiac Arrhythmias on HOMA-IR and Echocardiographic Parameters. A Randomized Double Blind, Placebo- Controlled Pilot Study. Clin Oncol. 2018; 3: 1484.