Journal Basic Info

  • Impact Factor: 2.709**
  • H-Index: 11 
  • ISSN: 2474-1663
  • DOI: 10.25107/2474-1663
**Impact Factor calculated based on Google Scholar Citations. Please contact us for any more details.

Major Scope

  •  Prostate Cancer
  •  Bladder Cancer
  •  Central Nervous System Tumors
  •  Colon Cancer
  •  Neoadjuvant Therapy
  •  Urological Cancers
  •  Head and Neck Oncology
  •  Chemoprevention

Abstract

Citation: Clin Oncol. 2017;2(1):1375.DOI: 10.25107/2474-1663.1375

Lactate: Metabolic Hallmark of Cancer in 21st Century

Gupta GS

Department of Biophysics, Panjab University, India

*Correspondance to: Gupta GS 

 PDF  Full Text Review Article | Open Access

Abstract:

Current understandings of lactate and tumor metabolism indicate that lactate acts as both a potent fuel (oxidative) and signaling molecule (angiogenesis and immune-suppression) in the body. Tumors that exhibit a “Warburg Effect,” are fueled by lactate through lactate shuttle. Reports suggest that the expression of LDH and the production of acidosis due to lactic acid from tumor cells facilitate the escape of cancer from immune surveillance. Cancer/germline (CG) antigens are promising targets for widely applicable mono and multi-antigen cancer vaccines for different cancers. While elevation of somatic LDH (LDH-A) is a well-studied marker in both solid and hematologic neoplasms, studies on cytogenetic changes of lung adenocarcinoma and their correlation with the role of LDH-C deserve future investigations. Sperm specific LDH-C, a cancer/testis antigen, and being highly immunogenicallo-antigen offers potential application in immunotherapy of cancers.

Keywords:

Cite the Article:

Gupta GS. Lactate: Metabolic Hallmark of Cancer in 21st Century. Clin Oncol. 2017; 2: 1375.

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