Clin Oncol | Volume 2, Issue 1 | Review Article | Open Access
Department of Biophysics, Panjab University, IndiaFulltext PDF
Current understandings of lactate and tumor metabolism indicate that lactate acts as both a potent fuel (oxidative) and signaling molecule (angiogenesis and immune-suppression) in the body. Tumors that exhibit a “Warburg Effect,” are fueled by lactate through lactate shuttle. Reports suggest that the expression of LDH and the production of acidosis due to lactic acid from tumor cells facilitate the escape of cancer from immune surveillance. Cancer/germline (CG) antigens are promising targets for widely applicable mono and multi-antigen cancer vaccines for different cancers. While elevation of somatic LDH (LDH-A) is a well-studied marker in both solid and hematologic neoplasms, studies on cytogenetic changes of lung adenocarcinoma and their correlation with the role of LDH-C deserve future investigations. Sperm specific LDH-C, a cancer/testis antigen, and being highly immunogenicallo-antigen offers potential application in immunotherapy of cancers.
Gupta GS. Lactate: Metabolic Hallmark of Cancer in 21st Century. Clin Oncol. 2017; 2: 1375.