Journal Basic Info

  • Impact Factor: 2.709**
  • H-Index: 11 
  • ISSN: 2474-1663
  • DOI: 10.25107/2474-1663
**Impact Factor calculated based on Google Scholar Citations. Please contact us for any more details.

Major Scope

  •  Hematology
  •  Chemotherapy and Radiotherapy
  •  Paediatric Cancers
  •  Hormone Therapy
  •  Breast Cancer
  •  Prostate Cancer
  •  Blood Cancer
  •  Immunotherapy

Abstract

Citation: Clin Oncol. 2017;2(1):1298.DOI: 10.25107/2474-1663.1298

Peripheral Blood Neutrophil to Lymphocyte Ratio is Positively Correlated with Tumour Aggressiveness in Testicular Cancer

Mustafa Ozan Horsanali, Kutan Ozer and Emin Ozbek


Department of Urology, Izmir Katip Çelebi University Ataturk Training and Research Hospital, Turkey

*Correspondance to: Mustafa Ozan Horsanali 

 PDF  Full Text Research Article | Open Access

Abstract:

Introduction: Testicular cancer represents between 1% to 1.5% of all male neoplasms and 5% of urological tumours in general. The Neutrophil to Lymphocyte Ratio (NLR), which can easily be calculated from routine Complete Blood Counts (CBCs) with differentials, is a marker of host inflammation and has been shown to be an independent prognosticator for a variety of solid malignancies.Materials and
Methods:
We have retrospectively analyzed 128 patients who diagnosed testicular cancer between January 2006 and July 2012. Patient demographics, preoperative full blood count and standard histologic tumour characteristics were recorded. Factors analyzed included patient age, tumour size, histological subtype, Pathological Tumour (pT) stage, N stage, neutrophil count, lymphocyte count, preoperative and postoperative NLR, alfa fetoprotein, B-HCG and LDH levels. Routine full blood count results were collected as part of the pre-treatment protocols.Results: Totaly 128 patients were analyzed retrospectively. The mean lymphocyte counts of all patients were 4.74 ±2.88 (range 0.32-5.72) and neutrophil counts were 5.93 ± 2.88 (range 1.87-17). The mean NLR was 3.70 ± 2.87 (range 1.04-21.94). The cut-off rate for NLR was calculated as 3,72. 87 patients were < 3,72 NLR and 41 patients were ≥3,72 NLR. The mean age for the group < 3,72 NLR were 41 (10,6%) and for group ≥3,72 NLR were 34,9 (8,5%) months. There were statistically significant association between age and NLR ratio (p: 0,002).Discussion: NLR is one of the widely used markers for systemic inflammatory reactions. Although increased pretreatment NLR is associated with a poor outcome for various types of cancers, we found a positive association between preoperative NLR and age, tumour histopathology, preoperative serum markers and rete testes invasion. In the group of NLR < 3,72 , tumour serum markers were lower than NLR>3,72 group. In the seminoma histopathology NLR value was < 3,72 and that was statistically significant.Conclusion: NLR is a simple, rapid and reliable method of how to evaluate the extent of stress or systemic inflammation. Our prognostic model based on the NLR and pathologic factors could be helpful in clinical practice. Also, clinicians should remember that baseline NLR differs among individuals.

Keywords:

Neutrophil; Lymphocyte; Neutrophil to lymphocyte ratio, Testis cancer; Stage

Cite the Article:

Horsanali MO, Ozer K, Ozbek E. Peripheral Blood Neutrophil to Lymphocyte Ratio is Positively Correlated with Tumour Aggressiveness in Testicular Cancer. Clin Oncol. 2017; 2: 1298.

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