Journal Basic Info

  • Impact Factor: 2.709**
  • H-Index: 11 
  • ISSN: 2474-1663
  • DOI: 10.25107/2474-1663
**Impact Factor calculated based on Google Scholar Citations. Please contact us for any more details.

Major Scope

  •  Cervical Cancer
  •  Pancreatic Cancer
  •  Blood Cancer
  •  Neoadjuvant Therapy
  •  Carcinomas
  •  Surgical Oncology
  •  Brain and Spinal Cord Cancer
  •  Lung Cancers

Abstract

Citation: Clin Oncol. 2017;2(1):1261.DOI: 10.25107/2474-1663.1261

Genetic Characterization of Choriocarcinoma and Potential Clinical Implications

Izildinha Maestá, Luz Angela Correa Ramírez, Julia Bette Homem de Mello, Marilza Vieira Cunha Rudge, Silvia R Rogatto


Department of Gynecology and Obstetrics, Botucatu Medical School, UNESP-Sao Paulo State University, Botucatu, SP, Brazil
Trophoblastic Diseases Center of the Botucatu Medical School, UNESP-Sao Paulo State University, Botucatu, SP, Brazil
Clinical Department, Caldas University, Manizales, Caldas, Colombia
International Research Center - AC Camargo Cancer Center, Sao Paulo, SP, Brazil
Department of Clinical Genetics, Vejle Sygehus and Institute of Regional Health, University of Southern Denmark, Vejle, Denmark

*Correspondance to: Izildinha Maest� 

 PDF  Full Text Mini Review | Open Access

Abstract:

Choriocarcinoma is a unique neoplasm that can occur after a pregnancy, as a component of germ cell tumors, or follow the trophoblastic differentiation of neoplastic somatic cells that completely lose their normal phenotype and produce hCG. Gestational Choriocarcinoma (GC) and Nongestational Choriocarcinoma (NGC) are pathologically and morphologically similar, but differ in genetic origin, immunogenicity, sensitivity to chemotherapy, and prognosis (with GC having a better prognosis than NGC). GC can follow any type of pregnancy, while NGC usually arises from ovarian germ cell tumors, or from any epithelial cancer. Approximately equal numbers of GC cases follow molar or non-molar pregnancies. The genetic make up of the tumor is determined by the nature of the antecedent pregnancy. Tumors resulting from term pregnancies, nonmolar abortions, or partial hydatidiform moles will have both maternal and paternal chromosomes, while those derived from complete hydatidiform moles will be androgenetic in origin. Although choriocarcinoma karyotypic analyses have shown no consistent chromosomal abnormalities, chromosomal gains, losses, and rearrangements have been identified. Distinguishing between GC and NC is clinically important in determining the prognosis and optimum management approach. The treatment of choice for GC is chemotherapy. Patients with NGC frequently respond well to initial chemotherapy, but will not be ultimately cured and should be managed more aggressively with surgical removaland multiagent chemotherapy.Although the overall survival of patients with choriocarcinoma receiving chemotherapy is high, some women still die due to chemoresistance. Identifying tumor origin by genetic parental analysesis essential to determine the prognosis and most appropriate treatment.

Keywords:

Cite the Article:

Maestá I, Ramírez LAC, de Mello JBH, Rudge MVC, Rogatto SR. Genetic Characterization of Choriocarcinoma and Potential Clinical Implications. Clin Oncol. 2017; 2: 1261.

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