Journal Basic Info

  • Impact Factor: 2.709**
  • H-Index: 11 
  • ISSN: 2474-1663
  • DOI: 10.25107/2474-1663
**Impact Factor calculated based on Google Scholar Citations. Please contact us for any more details.

Major Scope

  •  Carcinomas
  •  Chemoprevention
  •  Prostate Cancer
  •  Immunology
  •  Cervical Cancer
  •  Kidney Cancer
  •  Adjuvant Therapy
  •  Thoracic Oncology

Abstract

Citation: Clin Oncol. 2017;2(1):1259.DOI: 10.25107/2474-1663.1259

Long Term Follow-Up in Children Undergoing Nephron Sparing Surgery for Non-Syndromic Unilateral Wilms Tumor

Rajendra Nerli, Ranjeet Patil, Shridhar Ghagane and Murigendra B Hiremath

Department of Urology, KLE Kidney Foundation, India
Department of Biotechnology and Microbiology, Karnatak University, India

*Correspondance to: Rajendra Nerli 

 PDF  Full Text Research Article | Open Access

Abstract:

Introduction: Wilms Tumor (WT) represents approximately six to seven percent of all pediatric cancers and accounts for more than 95 percent of all tumors of the kidney in the pediatric age group. Recently some centers have explored the role of nephron sparing procedures in children with unilateral wilms tumors because of the concern about late occurrence of renal dysfunction after unilateral nephrectomy. We assessed the long term renal functional outcome after parenchymalsparing procedure for non-syndromic unilateral wilms tumor at our center.Materials and
Methods:
We retrospectively reviewed the records of all children with unilateral Wilms tumor who had undergone nephron sparing surgery at our center. Patient’s long-term renal function, tumor recurrence, and survival, were determined from a review of each patient’s medical record.Results: A total of eight patients underwent Partial Nephrectomy (PN) and the remaining three with polar tumors underwent Hemi-Nephrectomy (HN) following chemotherapy. Smaller tumor volumes were associated with not only preservation of renal function but also increase in eGFR during the follow-up period. The median preoperative eGFR was 106 ± 10.78 and median eGFR at the last follow-up was 131.0 ± 3.52.Conclusions: In properly selected children with non-syndromic unilateral Wilms tumor, nephron sparing surgery provides excellent renal function preservation.

Keywords:

Wilms tumor; Nephron sparing surgery; Child; Nephrectomy

Cite the Article:

Nerli R, Patil R, Ghagane S, Hiremath MB. Long Term Follow-Up in Children Undergoing Nephron Sparing Surgery for Non-Syndromic Unilateral Wilms Tumor. Clin Oncol. 2017; 2: 1259.

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