Clinical Outcomes of Adjuvant Therapies in Early Stage Invasive Cervical Cancer: More Research is Needed

Luz Angela Torres-de la Roche and Rudy Leon De Wilde

Department of Gynecology, University Medical School, Germany
Department of Obstetrics and Gynecological Oncology, Carl von Ossietzky University Medical School, Germany

^*Correspondance to: Rudy Leon De Wilde 

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Abstract:

Introduction: Uterine cervical cancer is one of the most common malignancies worldwide and the second most common gynecological cancer, specifically within the age group of 55–59 years. With the advancement in effective screening methods and treatment, patients with early stage disease have better prognosis now than before, but the impact of those therapies is not well known. The aim of this paper is to have a background about neoadjuvant therapies for early stage invasive cervical cancer, in order to guide our future research activities.Methods: Searches were conducted in PubMed, Medline, Orbisplus, Google Scholar and The Cochrane Library to identify relevant literature in English and German.Results: There is limited evidence about side effects of the combined radio-chemotherapy for uterine cervical cancer stages IIA und IIB. It was found no significant difference in survival at 5 years between women who received adjuvant therapy after surgery and those who received no further treatment (RR = 0.8; 95% IC 0.3-2.4), but the risk of disease progression was low for those who received radiation.Conclusion: More research is needed to add to the international knowledge about the effects of the therapies on the quality of health of the women with early invasive uterine cervical cancer. Furthermore, on the quality of care offered in different Cancer Centers.

Keywords:

Cervix uteri/radiation effects; Radiotherapy/radiotherapy adjuvant; Combined modality therapy; Antineoplastic combined chemotherapy protocols

Cite the Article:

Torres-de la Roche LA, De Wilde RL. Clinical Outcomes of Adjuvant Therapies in Early Stage Invasive Cervical Cancer: More Research is Needed. Clin Oncol. 2017; 2: 1237.