Role of ¹⁸F-FDG PET/CT in Gastric Carcinomas: Comparison with Contrastenhancement Computed Tomography

Gonca Kara Gedik, Farise Yılmaz, Mustafa Koplay and Oktay Sari

Department of Nuclear Medicine, Selçuk University, Turkey
Department of Radiology, Selcuk University Faculty, Turkey

^*Correspondance to: Gonca Kara Gedik 

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Abstract:

Purpose: The purpose of this study was to investigate the usefulness of 18Fluorodeoxyglucose Positron Emission Tomography /Computed Tomography (¹⁸F-FDG PET/CT) in patients with gastric carcinoma and to compare it with contrast enhancement CT.
Materials and Methods: The files of 20 patients (5 female, 15 male, mean age: 68 years) who underwent both ¹⁸F-FDG PET/CT and contrast enhancement CT for staging or restaging of gastric carcinoma were retrospectively evaluated. For each modality, the sensitivity, specificity, positive (PPV) and Negative Predictive Values (NPV) and accuracy was calculated in terms of gastric lesion detection, lymph node metastases or distant metastases. The diagnostic performances of two techniques were compared.
Results: For detecting gastric lesion, the sensitivity, specificity, PPV, NPV and accuracies of ¹⁸F-FDG PET/CT and contrast enhancement CT were 86%, 100%, 100%, 91%, 94% and 100%, 80%, 78%, 100% and 88%, respectively. In terms of lymph node metastases, the results were 75%, 71%, 60%, 83%, %73 and 88%, 92%, 88%, 92%, 90%, respectively. About distant metastases, the results were, 64%, 89%, 90%, 62%, 74% and 64%, 44%, 64%, 44%, 57%, respectively. The differences of the sensitivity and specificity of gastric lesion and metastatic lymph node detection were not statistically significant between two imaging techniques (p >0.05, McNemar test). ¹⁸F-FDG PET/CT appeared as a more specific modality than contrast enhancement CT for evaluating distant metastases in patients with gastric carcinoma but difference could not be found as statistically significant (p >0.05, McNemar test).Conclusion: ¹⁸F-FDG PET/CT is a useful diagnostic modality for the evaluation of gastric lesion and lymph node metastases and it has a comparable diagnostic performance with the standard imaging procedure of contrast enhancement CT in patients with gastric carcinoma. For distant metastases, complimentary usage of these techniques may be more beneficial in evaluation of patients with gastric carcinoma.

Keywords:

Gastric carcinoma; Positron emission tomography/computed tomography; Contrast enhancement computed tomography

Cite the Article:

Gedik GK, Y?lmaz F, Koplay M, Sari O. Role of 18F-FDG PET/CT in Gastric Carcinomas: Comparison with Contrastenhancement Computed Tomography. Clin Oncol. 2017; 2: 1221.