Journal Basic Info
**Impact Factor calculated based on Google Scholar Citations. Please contact us for any more details.Major Scope
- Ovarian Cancer
- Radiological Techniques and Scans
- Central Nervous System Tumors
- Brain and Spinal Cord Cancer
- Thoracic Oncology
- Palliative Care
- Neoadjuvant Therapy
- Carcinomas
Abstract
Citation: Clin Oncol. 2017;2(1):1220.DOI: 10.25107/2474-1663.1220
Malignant Transformation Potential of Dysembryoplastic Neuroepithelial Tumors
Kevin Yuqi Wang
Department of Radiology, Baylor College of Medicine, Houston, Texas, USA
*Correspondance to: Kevin Yuqi Wang
PDF Full Text Mini Review | Open Access
Abstract:
Dysembryoplastic neuroepithelial tumor is a relatively recently recognized neuropathological entity that was first proposed in 1988. It is typically considered either a quasi-hamartomatous lesion or a benign, low-grade mixed glioneuronal tumor, and is of World Health Organization grade I classification. Earlier studies suggested the clinical stability of this entity given the predominant lack of regrowth or recurrence on long-term follow-up, even in setting of subtotal resection. However, there is increasing evidence to suggest the possibility of atypical behavior including post-resection recurrence and malignant transformation. Mutagenic effects of adjuvant radiotherapy, subtotal resection, contrast enhancement, and high proliferative activity as reflected by Ki67 labeling index have been postulated as risk factors to malignant transformation. However, ultimately, the rare occurrence, limited descriptions, and conflicting findings in the literature preclude confidently making any meaningful conclusions on this phenomenon.
Keywords:
Magnetic resonance imaging; Dysembryoplastic neuroepithelial tumor; Astrocytoma; Oligodendroglioma; Malignant transformation
Cite the Article:
Wang KY. Malignant Transformation Potential of Dysembryoplastic Neuroepithelial Tumors. Clin Oncol. 2017; 2: 1220.