Endocrine Disrupting Compounds and Prostate Cell Proliferation

Joubert Banjop Kharlyngdoh and Per-Erik Olsson

Department of Biology, Örebro University, Sweden

^*Correspondance to: Per-Erik Olsson 

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Abstract:

Epidemiological, in vitro and animal studies have indicated that Endocrine Disrupting Compounds (EDCs) influence the normal growth and development of the prostate as well as development and progression of prostate cancer. This has been linked to an increased presence of environmental chemicals that interfere with hormonal signaling. Many of these effects appear to be associated with interferences with steroid hormone receptor signaling or by affecting steroidogenesis. Currently, there is abundant evidence from epidemiological studies linking pesticides and EDCs with elevated prostate cancer risk. Bisphenol-A, a known EDC, has been shown to promote induction of Prostate Specific Antigen (PSA), which is a biomarker for prostate cancer, in the LNCaP human prostate carcinoma cells, and to increase prostate carcinogenesis in animal models. Our research has focused on AR signaling and identification of novel androgenic and anti-androgenic EDCs. Using prostate cancer cell lines we have shown that the AR agonist, TBECH, and antagonist ATE, which is also a partial ART877A agonist, induce PSA expression. With the increasing presence of these EDCs in indoor and outdoor air, follows an increased risk of disturbed prostate development, regulation and function. Hence, identification of the contribution of EDCs to prostate cancer development should be considered a high priority.

Keywords:

Endocrine disrupting compounds; Androgen receptor; Prostate cancer

Cite the Article:

Kharlyngdoh JB, Olsson P-E. Endocrine Disrupting Compounds and Prostate Cell Proliferation. Clin Oncol. 2016; 1: 1116.