November, 2017

Review Article

Predictive Markers of Efficacy

Cancer treatments have long relied on predictive markers of efficacy. Once a chemotherapy drug or regimen is shown to be efficacious for a particular tumor type, that becomes the predictive marker of efficacy.

Published 23 Nov, 2017


New Therapy for Merkel Cell Carcinoma (MCC), a Non-Melanoma Skin Cancer

PET images of an81 year old man with stage IV Merkel cell carcinoma before (2/24/17) and after (6/28/17 and 8/29/27) pembrolizumab therapy. Metastases are seen in the right axilla, bilateral mediastinum, left lung, liver, retroperitoneal nodes, skeleton (SUV 4.7 to 13.6, left).

Published 22 Nov, 2017

Short Communication

Primary and Secondary Circulating Prostate Cells: Theoretical Considerations and Clinical Utility

Although circulating tumor cells were first reported in 1869; [1] it has not been until the last few decades that technological advances have permitted an improved detection and isolation of these rare cells from the blood.

Published 24 Nov, 2017


Perspective: Imaging for Gliomas

The 2016 World Health Organization (WHO) classification of tumors of the central nervous system (CNS) broadly employs genetic alterations for diagnostic criteria, including isocitrate dehydrogenase-1 (IDH1) mutation or IDH2 mutation and 1p/19q codeletion [1], with the goal of creating more homogenous disease categories with greater prognostic value [2-5].

Published 24 Nov, 2017


Natural Products and their Attributes in Oncology Area: Hope on the Horizon?

Cancer is the general name of a heterogeneous group of more than 100 diseases.

Published 23 Nov, 2017

Short Communication

Detection of PDL-1 as of Biomarker in Checkpoint Blockade Therapy

Immune checkpoints are a series of pathways which can regulate T cell activity as either coinhibitory or co-stimulatory signals [1].

Published 25 Nov, 2017

Review Article

Molecular Hydrogen as a Novel Therapeutic Tool in Situations of Increased Production of Free Radicals

Excessive production of oxygen and nitrogen radicals has been regarded as a causative common denominator of many pathological processes.

Published 26 Nov, 2017

Review Article

Addressing the Challenges of HIV/AIDS-Defining Non-Hodgkin’s Lymphomas in Sub-Saharan Africa

Southern Africa has the highest HIV incidence worldwide. Thus far there is no cure; however, the lives of individuals infected with the virus can be prolonged through the use of Highly Active Anti-Retroviral Therapy (HAART).

Published 12 Nov, 2017


Subungal Squamous Cell Carcinoma - A Missed Diagnosis

Subungal squamous cell carcinoma is a rare entity. These tumours may present with nail plate discolouration or deformity, paronychia, ulceration and pain, usually affecting a single digit.

Published 10 Nov, 2017


Current Trends in Allogeneic Hematopoietic Stem Cell Transplantation

Hematopoietic stem cell transplantation (HSCT) has proven to be a curative treatment strategy for patients with many malignant and non-malignant hematological disorders, including leukemia, lymphomas and aplastic anemia, and indications are still expanding.

Published 10 Nov, 2017

Clinical Image

Early Pharyngeal Cancer Treated by ESD

In recent years, improvement of image quality of endoscopes, especially progress of image enhanced endoscopy (IEE) has made it possible to point out neoplastic lesions in pharyngeal laryngeal region even in the early stage byendoscopists.

Published 10 Nov, 2017


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