Case Report

Excellent Response to Dual Her2 Targeted Therapy in a Patient with Advanced Colorectal Cancer in Fourth Line of Treatment

Men 47 years old with staged IV colon cancer Ras wild type and her 23+, who had progressed to all approved treatments, get an spectacular response with dual her2 targeted Therapy without chemotherapy.

Published 06 Dec, 2016


Research Article

Automatisation of the Gleason Score, The End of the Dilemma? A Proposal to Increase Consensus

Introduction: The updated Gleason score (GS) (WHO classification 2016) decreases interobserver variability, but discordance still exists

Published 05 Dec, 2016


Review Article

Primary Adenoid Cystic Carcinoma of Lung – An Overview

Adenoid cystic carcinoma of the lung is a rare salivary gland-type neoplasm. Due to the rarity of the disease, its clinicopathological behaviour and management principles are poorly understood.

Published 05 Dec, 2016


Editorial

Palliative Care Unit in an Oncology Hospital in Turkey

Palliative care is defined by the World Health Organization as 'an approach that improves the quality of life of patients and their families facing the problem associated with life-threatening illness, through the prevention and relief of suffering by means of early identification and impeccable assessment and treatment of pain and other problems, physical, psychosocial, and spiritual' [1].

Published 05 Dec, 2016


Review Article

Current Management of Duodenal Gastrointestinal Stromal Tumors

Gastrointestinal stromal tumors (GISTs) originating in the duodenal wall constitute the most challenging localization for this gastrointestinal neoplasm.

Published 02 Dec, 2016


Review Article

Prostatitis: Recent Update on Etiopathogenesis, Molecular Diagnosis and Role in the Genesis of Benign Prostatic Hyperplasis (BPH) & Prostatic Carcinoma (Pca)

Prostatitis is a common problem in elderly. Prostatitis is causd by implantation of gram negative organism by direct route or lymphohematogenous route, instrumentation, inoculation of BCG for bladder cancer & occasionally as a part of military tuberculosis involving genitourinary system.

Published 02 Dec, 2016


Case Report

Cystic Prostatic Carcinoma

We report a rare case of prostatic carcinoma associated with cystic degeneration. Cystic masses within the prostate are known.

Published 02 Dec, 2016


Case Report

Targeted Therapy’s Skin Toxicities after Immunotherapy: Skin Toxicity of Tyrosine Kinase Inhibitor Therapy Following Nilovumab Therapy for Metastatic Renal Cell Carcinoma

Anti-programmed cell death antibodies (anti-PD-1) are currently under development for the treatment of metastatic renal cell carcinoma (mRCC) and safety of subsequent treatment by VEGFR tyrosine kinase inhibitors (TKI) is not known.

Published 01 Dec, 2016


Case Series

Could Detailed Alk-Status Reporting Help Better Understand Therapy Response to Crizotinib?

Anaplastic lymphoma kinase (ALK) rearrangements have been found to be actionable mutations in non-small cell lung cancer (NSCLC).

Published 01 Dec, 2016


Review Article

Exosomes: Secreted Membrane Micro Vesicles that Mediate Intracellular Communications

Exosome is an nano-particle with diameter of 40-100nm, generated in endosomes with bioactive molecules incorporated into lipid bilayer envelope.

Published 01 Dec, 2016


Research Article

Genistein Induced Apoptosis of Gastric Cancer Cell through Bcl-2 and Caspase-3 Regulation

Aim: To investigate the effects of genistein on cell apoptosis in the human gastric cancer cell BGC- 823 and the potential regulation pathway involved in its apoptotic effect.

Published 30 Nov, 2016


Case Report

Orbital Myositis Secondary to Cytotoxic T-Lymphocyte-Associated Protein 4 Antibody – A Case Report

Ipilimumab, a monoclonal antibody targeting cytotoxic T-lymphocyte antigen 4 (CTLA-4) was approved in 2011 for the treatment of metastatic melanoma after a phase 3 study showed an improvement in overall survival.

Published 30 Nov, 2016


Review Article

Applications of DECT in Thoracic Oncology: Evidence So Far

There is mounting evidence in favor of applying Dual Energy CT (DECT) for evaluation of suspected or known thoracic malignancies

Published 29 Nov, 2016


Research Article

Anatomic Trisegmentectomy: An Alternative Treatment for Huge or Multiple Hepatocellular Carcinoma of Right Liver

Background: The patients with huge (≥10 cm) or multiple Hepatocellular Carcinoma (HCC) in right liver and insufficient volume of remnant left liver cannot be performed right hemihepatectomy in that liver failure will occur post operation.

Published 29 Nov, 2016


Case Report

Complete Pathologic Response of Pancreatic Adenocarcinoma to Chemotherapy (FOLFIRINOX) is not equal to Cure: Case Report and Review of the Literature

Pancreatic ductal adenocarcinoma may present as locally advanced disease in a significant percentage of patients.

Published 28 Nov, 2016


Case Report

Intracranial Dural Marginal Zone Lymphoma: A Case Report

We present a case of low grade Marginal Zone Lymphoma (MZL) presenting as a dural mass in a 21 year old woman.

Published 28 Nov, 2016


Editorial

Research Interest and Projects

Managing complex shoulder disorders as result of brachial plexus injury (obstetric or adult), or significant bone or soft tissue deficiency secondary to injury, advanced degenerative changes or tumor resection could be very challenging.

Published 25 Nov, 2016


Case Report

First Report of Propionibacterium acnes in Prostate from Chilean Patients

Introduction: In prostate, inflammatory foci are usual and could be associated with chronic infections, and later with cancer development.

Published 25 Nov, 2016


Case Report

Quadruple Hepatic Arteries in Patient with Hepatocellular Carcinoma: Case Report

A 58-year-old woman who had recently developed vague right-sided abdominal pain. Pre-contrast and triphasic CT scans were performed by using a 64 multi-detector CT scanner.

Published 24 Nov, 2016


Case Report

Emerging Treatment Options for Adolescents and Young Adults with Relapsed or Refractory Lymphoma

Lymphomas are amongst the most common cancers in Adolescents and Young Adults (AYA). Despite favorable outcomes with upfront therapy, survival in patients with relapsed or refractory disease remains poor.

Published 23 Nov, 2016





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