Review Article

Evolution of a System to Increase Precision in the Surgical Management of Colorectal Carcinoma

Current surgical procedures for colorectal adenocarcinoma are plagued by a lack of precise information due to lack of sensitivity and specificity of preoperative imaging and surgical limitations in the Operating Room using traditional techniques (i.e., inspection and palpation).

Published 05 May, 2017


Review Article

Pivotal Role of Lymph Node Sinus Macrophages and Anti-Tumor Immune Responses in Patients with Malignant Tumors

Recent progress in anti-tumor therapy has revealed the significance of anti-tumor immune responses in tumor progression and clinical course in several kinds of malignant tumor.

Published 05 May, 2017


Review Article

The Role of Electromagnetic Pollution in Cancer

Exposure to non-ionizing Electromagnetic Frequencies (EMF) that include extremely low frequency electric and magnetic fields, intermediate frequencies commonly referred to as dirty electricity, and both radio frequency and microwave wave radiation has been increasing.

Published 05 May, 2017


Short Communication

Arachidonate-5-Lipoxygenase (ALOX5): A Master Regulator for Prostate Cancer Cell Survival

Metabolic reprogramming has been recognized as a hallmark of cancer. Cancer cells grow and divide much more rapidly than normal cells, meaning that they have much higher demand for nutrients and oxygen.

Published 04 May, 2017


Editorial

Combined Positron Emission Tomography and Magnetic Resonance Imaging: A Technical Challenge

A clinical prototype of combined Combined Positron Emission Tomography (PET) / Computed Tomography (CT) system went under the clinical evaluation in 1998.

Published 04 May, 2017


Research Article

Assessment of PTV Margins Accounting for Prostate Intrafraction Motion in SBRT with Online IGRT

Purpose: The aim of this work was to assess PTV margins suitable for SBRT of prostate cancer uncertainties after daily online correction.

Published 04 May, 2017


Short Communication

Histone Methylation in Relation with Clinical Pathological Parameters in Prostate Cancer

DNA and histone methylation are both modifications closely link to stable repression. However, previous studies have shown that methylation repression by EZH2 could be an independent epigenetic mechanism of DNA methylation [1].

Published 04 May, 2017


Case Report

Primary Lymphoma of the Sacrum- A Rare Entity

Primary lymphomas of the bone are rare neoplasm accounting for approximately 0.4% of all primary bone tumours.

Published 04 May, 2017


Short Communication

Beyond Systemic Anti-PD-1 and CTLA-4 in Advanced Melanoma - Is Intratumoral Therapy the Answer?

Since the FDA approval of ipilimumab (Yervoy) in 2011, systemic Checkpoint Inhibitors (CPIs) targeting Cytotoxic T-Lymphocyte-Associated Protein 4 (CTLA-4) and programmed cell protein 1 (PD-1/PD-L1) have significantly improved the overall survival for patients with a variety of cancer types, including, but not limited to, malignant melanoma, non-small cell lung cancer, urothelial cancer, renal cell carcinoma, and squamous cell cancers of the head and neck.

Published 04 May,, 2017


Short Communication

Nuclear Medicine: The Future in the Modern Healthcare

At the state of art, the practice of medicine is projected toward a "personalized” approach and to find diagnostic and treatment pathways specific for patient's characteristics and his disease.

Published 04 May, 2017


Case Report

Effects and Side Effects of Nivolumab: From Pneumonitis to Complete Remission Complete Response of Metastatic NSCLC after Resolution of a Pneumonitis on Nivolumab Treatment

Non-Small Cell Lung Cancer (NSCLC) without driver mutations has limited the rapeutic options beyond first line chemo therapy.

Published 01 May, 2017


Case Report

Two Patients with Advance-Stage Renal Cell Carcinoma Developed Sunitinib-Related Skin Toxicity

With the current treatment modalities like molecular targeted therapy, general survival rates have increased in patients with advanced-stage renal cell carcinoma.

Published 26 Apr, 2017


Research Article

Physical, Emotional and Spiritual Well-Being, Dignity and Hope in Adult Patients with Solid and Hematologic Malignancies, on Cure or Follow-Up

Introduction: In oncological setting, the assessment of physical/emotional symptoms and above all of existential/religious needs and resources, hope and dignity are rarely performed in the routine clinical practice.

Published 26 Apr, 2017


Research Article

Improved Utilization of Resources as an Improvement of Outcome: the Effect of Multidisciplinary Team for Rectal Cancer in a District Hospital

Aim: Today, treatment decisions about patients with rectal cancer are increasingly made within the context of a Multi-Disciplinary Team (MDT) meeting.

Published 26 Apr, 2017


Case Report

Acute Esophageal Necrosis Complicated by Severe Upper Gastrointestinal Bleeding in Association with Bosutinib Treatment for Chronic Myelogenous Leukemia

Acute Esophageal Necrosis (AEN), also known as “Black Esophagus”, is a rare life threatening condition with unknown cause.

Published 26 Apr, 2017


Review Article

Circulating Tumor DNA as a Liquid Biopsy in Cancer

Circulating tumor DNA represents a promising biomarker for non-invasive assessment of cancer progression and evolution.

Published 24 Apr, 2017


Editorial

Hereditary Colon Cancer Syndromes: Optimal Management in 2017

Colorectal Cancer (CRC) is the third most common cancer in the United States [1]. Almost onethird of the cases show familiar predisposition and a genetic syndrome is identified in approximately 5% of newly diagnosed patients [2].

Published 24 Apr, 2017


Editorial

Sunscreen- The Double Edged Sword

Sunscreens have long being recognized as substances to provide effective protection against the detrimental effects of solar radiation.

Published 14 Apr, 2017


Case Report

Lipofibromatosis of the Paravertebral Soft Tissue in a Child of Two Years Old

Lipofibromatosis is a bland fibroproliferative process that invades skeletal muscle. Typically the children are affected before 8 years with a peak under 2 years old.

Published 14 Apr, 2017


Mini Review

Genetic Characterization of Choriocarcinoma and Potential Clinical Implications

Choriocarcinoma is a unique neoplasm that can occur after a pregnancy, as a component of germ cell tumors, or follow the trophoblastic differentiation of neoplastic somatic cells that completely lose their normal phenotype and produce hCG.

Published 07 Apr, 2017





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